The Present Status of Sulphones in the Treatment of Leprosy

The Present Status of Sulphones in the Treatment of Leprosy

ELISA inhibition technique for the demonstration of sulphones in body fluids. I. Sulphones specific antibody-enzyme conjugate.

Two enzyme-linked immunosorbent assays ( ELISA) for sulphones in body fluids were adapted to measure sulphones in blood dried on filter paper. The more sensitive modification , based on competition between dapsone (DDS) and enzyme-dapsone conjugate , detects sulphone in blood extracts up till 6 days following 1 00 mg DDS intake . Application to monitor patient compliance is demonstrated, using ...

Dapsone and its uses in dermatology

Dapsone first came into medicine as an antibacterial agent but was found to be less effective than other sulfonamides. Likewise its activity against tuberculosis was disappointing. Nevertheless, it has been the main stay in the treatment of leprosy. It also has some action against malaria and other parasites. Nowadays, after leprosy, dapsone has proved as a valuable drug in the treatment of a w...

Sclerotherapy: a bloodless approach in treatment of pyogenic granuloma in children

Pyogenic granuloma (PG) is a common, acquired tumor-like growth occurring on skin/mucous membranes. It is prevalent in the pediatric age group. It is benign in nature and is caused by chronic low grade trauma. It presents as pink to red elevated pedunculated or sessile mass. There are various treatment modalities including surgery, cryotherapy, laser, electrocautery, etc. However, the therapeut...

The chemotherapy of leprosy: an interpretive history.

The introduction of effective antimicrobial treatment for leprosy, first with the sulphones by Faget in 1943, was the major scientific development of the twentieth century to actually alter disease course and provide patients reason to hope. Initially promin and solapsone, injectable sulphones, were utilised, but these injectables were soon abandoned for oral dapsone which had the additional ad...